Cyclooxygenase-2 expression in female pulmonary adenocarcinoma

Abstract

Objective To explore the relationship between the expression of COX-2 and pathophysiological features in female pulmonary adenocarcinoma patients. Methods Expression of COX-2 protein was detected in 50 cases of female pulmonary adenocarcinoma tissues and 50 cases of paracancerous tissues by streptavidin-biotin immunoperoxidase method. Results The positive rates of COX-2 expression were 78% and 26% in tumor tissues and paracancerous tissues respectively, and there was a highly significant difference between the two groups (χ2=27.08, P < 0.01). No significant difference was found among COX-2 expression level, age (P=0.50), smoking history (P=1.0), differentiation grade of tumor cells (P=0.712), TNM stage (P=0.591), size of primary tumor (P=0.63) and lymph nodes metastasis (P=0.88). Conclusion Overexpression of COX-2 may play an important role in oncogenesis of female lung adenocarcinoma.

DOI: 10.3779/j.issn.1009-3419.2002.02.08